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CCL8 Antibody / MCP2

CAT: 0800-V9560SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9560SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This anti-microbial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P80075
Host
Mouse
Reactivity
Human
Immunogen
A portin of amino acids 1-99 from the human protein was used as the immunogen for the CCL8 antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
CCL8/3683
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the CCL8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CCL8 antibody is available for research use only.
Storage Conditions
Aliquot the CCL8 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the CCL8 antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC staining of FFPE human adrenal gland with CCL8 antibody (clone CCL8/3683) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P80075

C-C motif chemokine 8

CCL8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P80075
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCL8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0AV77, P78388
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

Molecular function

CytokineHeparin-binding

PTM

Disulfide bondPyrrolidone carboxylic acid

Cellular component

Secreted

Domain

Signal

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