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MCP2 Antibody / CCL8

CAT: 0800-V9514-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9514-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL
UniProt
P80075
Host
Mouse
Reactivity
Human
Immunogen
A portin of amino acids 1-100 from the human protein was used as the immunogen for the MCP2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CCL8/3311
Applications
IHC-P, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MCP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MCP2 antibody is available for research use only.
Storage Conditions
Aliquot the MCP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the MCP2 antibody should be determined by the researcher.
Location
Secreted
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using MCP2 antibody (clone CCL8/3311) . These results demonstrate the foremost specificity of the CCL8/3311 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

UniProtKB · P80075

C-C motif chemokine 8

CCL8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P80075
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCL8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0AV77, P78388
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

Molecular function

CytokineHeparin-binding

PTM

Disulfide bondPyrrolidone carboxylic acid

Cellular component

Secreted

Domain

Signal
Product Datasheet
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