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NTN3 Antibody / Netrin 3

CAT: 0800-RQ8454Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ8454Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Netrins are a family of highly conserved proteins responsible for axon guidance and cell movement throughout neural development. Netrins can be divided into secreted netrins (netrin 1,3,4 and 5) and membrane-tethered glycophosphatidylinositol (GPI) -linked netrins (netrin G1 and G2) . Secreted netrins carry their function via interaction with several receptors that include the deleted in colorectal (DCC) family, and the uncoordinated-5 (UNC5-A through UNC5-D) family. Netrin-3 was discovered in 1997 using sequence homology searching of netrin-2. Similarly to other netrins, Netrin-3 plays an important role in the development of the nervous system. Netrin-3 structure consist of a laminin-like domain located on the N-terminal, three epidermal growth factors like repeats (EGF), and a C-terminal netrin-like domain (NTR) . Mutations in NTN3, the gene encoding netrin-3 was found to be associated with the development of several carcinomas.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, ELISA: 0.1-0.5 µg/mL
UniProt
O00634
Host
Rabbit
Reactivity
Human, Rat
Immunogen
An E.coli-derived human recombinant protein (R51-R473) was used as the immunogen for the NTN3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the NTN3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This NTN3 antibody is available for research use only.
Storage Conditions
After reconstitution, the NTN3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the NTN3 antibody should be determined by the researcher.
Image Legend
Immunofluorescent staining of FFPE human HeLa cells with NTN3 antibody (red) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · O00634

Netrin-3

NET3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00634
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NTN3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

PTM

Disulfide bondGlycoprotein

Cellular component

Extracellular matrixSecreted

Domain

Laminin EGF-like domainRepeatSignal

Technical term

Proteomics identificationReference proteome
Product Datasheet
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