CCNH Recombinant Antibody / Cyclin H

CCNH Recombinant Antibody / Cyclin H

• Description: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. [UniProt]
• CAS Number: 9000-83-3
• UniProt: P51946
• Host: Rabbit
• Immunogen: A synthetic peptide derived from human Cyclin H/p34 was used as the immunogen for the CCNH antibody.
• Clonality: Monoclonal
• Isotype: IgG
• Type: Recombinant
• Applications: WB
• Format: Purified
• Buffer: Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
• Reconstitution: Store the CCNH antibody at -20oC.
• Limitations: This CCNH antibody is available for research use only.