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MMACHC Antibody / CblC

CAT: 0800-RQ8304Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ8304Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methylmalonic aciduria and homocystinuria type C protein (MMACHC) is a protein that in humans is encoded by the MMACHC gene. The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, ELISA: 0.1-0.5 µg/mL
UniProt
Q9Y4U1
Host
Rabbit
Reactivity
Human
Immunogen
An E.coli-derived human recombinant protein (M1-K242) was used as the immunogen for the MMACHC antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the MMACHC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MMACHC antibody is available for research use only.
Storage Conditions
After reconstitution, the MMACHC antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MMACHC antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of fixed and permeabilized human JK cells with MMACHC antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= MMACHC antibody.

UniProtKB · Q9Y4U1

Cyanocobalamin reductase / alkylcobalamin dealkylase

MMAC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y4U1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MMACHC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5T157, Q9BRQ7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CobalaminCobaltFADFlavoproteinFMNNADP

Cellular component

Cytoplasm

Disease

Disease variant

Molecular function

OxidoreductaseTransferase

PTM

Phosphoprotein

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