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Dtr Antibody / Hbegf

CAT: 0800-RQ8280Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ8280Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Heparin-binding EGF-like growth factor (HB-EGF), also called Diphtheria toxin receptor (Dtr) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. Enables epidermal growth factor receptor binding activity; growth factor activity; and heparin binding activity. Involved in positive regulation of keratinocyte migration; positive regulation of smooth muscle cell proliferation; and wound healing, spreading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch; heart; oral region gland; telencephalon; and tooth. Human ortholog (s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor) .
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, ELISA: 0.1-0.5 µg/mL
UniProt
Q06186
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
An E.coli-derived mouse recombinant protein (D63-L148) was used as the immunogen for the Dtr antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Dtr antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Dtr antibody is available for research use only.
Storage Conditions
After reconstitution, the Dtr antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Dtr antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat heart and 2) mouse heart tissue lysate with Dtr antibody. Predicted molecular weight ~23 kDa but may be observed at higher molecular weights due to glycosylation.

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