Products for Research Use Only
RegisterLogin

PNPLA6 Antibody / NTE

CAT: 0800-RQ8014Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-RQ8014Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Neuropathy target esterase (NTE), also known as patatin-like phospholipase domain-containing protein 6 (PNPLA6), is an esterase enzyme that in humans is encoded by the PNPLA6 gene. This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q8IY17
Host
Rabbit
Reactivity
Human
Immunogen
E. coli-derived recombinant human protein (amino acids H15-E1296) was used as the immunogen for the PNPLA6 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the PNPLA6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PNPLA6 antibody is available for research use only.
Storage Conditions
After reconstitution, the PNPLA6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PNPLA6 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Immunofluorescent staining of FFPE human U-2 OS cells with PNPLA6 antibody (red) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · Q8IY17

Patatin-like phospholipase domain-containing protein 6

PLPL6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IY17
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PNPLA6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.1.5
Processing
—
Secondary accessions
A6NGQ0, B4DFB9, B7Z7T2, F5H5K9, J3KQS3, O60859, Q86W58, Q9UG58
Protein keywords

Coding sequence diversity

Alternative splicing

Disease

Disease variantDwarfismHereditary spastic paraplegiaHypogonadotropic hypogonadismIntellectual disabilityNeurodegenerationRetinitis pigmentosa

Cellular component

Endoplasmic reticulumMembrane

PTM

GlycoproteinPhosphoprotein

Molecular function

Hydrolase

Biological process

Lipid degradationLipid metabolism

Technical term

Proteomics identificationReference proteome

Domain

RepeatTransmembraneTransmembrane helix
Product Datasheet
Loading...

Related Products

CatalogName
F54286-0.08MLPNPLA3 Antibody
R33792-100UGPNPLA3 Antibody
F54286-0.4MLPNPLA3 Antibody
R34823-100UGATGL Antibody / PNPLA2
F53952-0.2MLAntibody
F53952-0.05MLAntibody
RQ4624NONO Antibody / p54nrb Antibody
F53954-0.2MLAntibody
F53954-0.05MLAntibody
V8674SAF-100UGInhibin alpha Antibody / INHA antibody

Alternative Products

CatalogName
70R-8660Pnpla6 antibody

Popular Products