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Muromonab Biosimilar - Research Grade

CAT: 1148-ICH5024-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:1148-ICH5024-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Muromonab is an immunosuppressant drug given to reduce acute rejection in patients with organ transplants. It is a monoclonal antibody targeted at the CD3 receptor, a membrane protein on the surface of T cells. It was the first monoclonal antibody to be approved for clinical use in humans.
Specifications
Detects human CD3 epsilon OKT-3. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Muromonab.
Product Name Alternative
OKT-3
UniProt
P07766
Species Reactivity
Human
Target
CD3e
Applications
Functional Assays
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
5mg/mL
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE
Buffer
ICH3002
Shipping Conditions
Blue ice
Storage Conditions
This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
Formulation
Sterile, preservative-free, solution in PBS. BSA and Azide free.
Applications Notes
This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.

UniProtKB · P07766

T-cell surface glycoprotein CD3 epsilon chain

CD3E_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07766
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD3E
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K997
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Cellular component

Cell membraneMembrane

PTM

Disulfide bondPhosphoprotein

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Molecular function

Receptor

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