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Sutimlimab Biosimilar - Research Grade

CAT: 1148-ICH5012-10mgSize: 10 mg (2x 5 mg)Dry Ice: NoHazardous: No
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CAT#:1148-ICH5012-10mgSize:10 mg (2x 5 mg)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RUO sutimlimab biosimilar is a humanized monoclonal antibody that is designed to selectively target and inhibit C1s in the classical complement pathway, which is part of the innate immune system. By blocking C1s, sutimlimab inhibits the activation of the classical complement pathway with the goal of halting C1-activated hemolysis in cold agglutinin disease to prevent the abnormal destruction of healthy red blood cells. By selectively inhibiting the classical pathway upstream at C1s, sutimlimab does not inhibit the lectin and alternative complement pathways.
Specifications
Detects human C1s. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Sutimlimab.
UniProt
P09871
Species Reactivity
Human
Target
C1s
Isotype
IgG4
Applications
Functional Assays
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
5mg/mL
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE
Buffer
ICH3002
Shipping Conditions
Blue ice
Storage Conditions
This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
Formulation
Sterile, preservative-free, solution in PBS. BSA and Azide free.
Applications Notes
This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Isotype Control
https://ichor.bio/product/bulk-human-igg4-isotype-control-ib4-ich2257/

UniProtKB · P09871

Complement C1s subcomponent

C1S_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09871
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
C1S
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.42
Processing
Precursor
Secondary accessions
D3DUT4, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Biological process

Complement pathwayImmunityInnate immunity

Disease

Disease variantEhlers-Danlos syndrome

PTM

Disulfide bondGlycoproteinHydroxylation

Domain

EGF-like domainRepeatSignalSushi

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

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