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Tocilizumab Biosimilar - Research Grade

CAT: 1148-ICH4012-1mgSize: 1 mgDry Ice: NoHazardous: No
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CAT#:1148-ICH4012-1mgSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tocilizumab is a recombinant humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody of the immunoglobulin IgG1κ (gamma 1, kappa) subclass with a typical H2L2 polypeptide structure. Each light chain and heavy chain consists of 214 and 448 amino acids, respectively. The four polypeptide chains are linked intra- and inter-molecularly by disulfide bonds. Tocilizumab has a molecular weight of approximately 148 kDa. The antibody is produced in mammalian (Chinese hamster ovary) cells.
Specifications
Detects human IL-6 receptor. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Tocilizumab.
Product Name Alternative
IL6R
UniProt
P08887
Host
Humanized
Species Reactivity
Human
Target
IL-6 receptor
Purification Method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
1.0 - 5.0 mg/mL
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Purity
>95% by SDS-PAGE and HPLC
Buffer
ICH3001-100mL ICH3002-100mL ICH3003-100mL
Shipping Conditions
Blue ice
Storage Conditions
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.
Isotype Control
https://ichor.bio/product/bulk-human-igg1-isotype-control-ib1-ich2254/

UniProtKB · P08887

Interleukin-6 receptor subunit alpha

IL6RA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08887
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL6R
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA
EC number
—
Processing
Precursor
Secondary accessions
A8KAE8, B2R6V4, Q16202, Q53EQ7, Q5FWG2, Q5VZ23
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

Receptor

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