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PLC-delta-3 Antibody / PLCD3

CAT: 0800-RQ7952Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7952Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene. This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3) . Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca (2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunofluorescence (FFPE) : 5 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q8N3E9
Host
Rabbit
Reactivity
Human
Immunogen
E. coli-derived recombinant human protein (amino acids R10-Q702) was used as the immunogen for the PLC-delta-3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the PLC-delta-3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PLC-delta-3 antibody is available for research use only.
Storage Conditions
After reconstitution, the PLC-delta-3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PLC-delta-3 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Immunofluorescent staining of FFPE human HL60 cells with PLC-delta-3 antibody (red) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · Q8N3E9

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

PLCD3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8N3E9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PLCD3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.4.11
Processing
—
Secondary accessions
Q8TEC1, Q8TF37, Q96FL6
Protein keywords

Ligand

CalciumMetal-binding

Cellular component

Cell membraneCytoplasmMembrane

Molecular function

HydrolaseTransducer

Biological process

Lipid degradationLipid metabolism

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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