BRD4 ligand-Linker Conjugate 1 (TFA)

BRD4 ligand-Linker Conjugate 1 (TFA)

• UNSPSC Description: BRD4 ligand-Linker Conjugate 1 TFA (compound 106-1) is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs[1][2].
• Target Antigen: Target Protein Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/brd4-ligand-linker-conjugate-1-tfa.html
• Purity: 98.66
• Solubility: 10 mM in DMSO|H2O : 100 mg/mL (ultrasonic)
• Smiles: ClC1=CC=C(C2=NC3(CC3)C4=NN=C(C)N4C5=CC=C(C6=CN(CCCCCCN)N=C6)C=C25)C=C1.OC(C(F)(F)F)=O
• Molecular Weight: 614.06
• References & Citations: [1]Sun D, et al. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20(8):1367-1377.|[2]Phillips AJ, et al. Preparation of bromodomain targeting degronimers for target protein degradation. World Intellectual Property Organization, WO2017197056 A1. 2017-11-16.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen, away from moisture)
• Clinical Information: No Development Reported