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UNC5D Polyclonal Antibody

CAT: 0965-JOT-AP15364-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP15364-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,PTM:Phosphorylated on cytoplasmic tyrosine residues.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,Belongs to the unc-5 family.,Contains 1 death domain.,Contains 1 Ig-like (immunoglobulin-like) domain.,Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,Contains 1 ZU5 domain.,Contains 2 TSP type-1 domains.,subunit:Interacts with the cytoplasmic part of DCC.,
CAS Number
9007-83-4
Synonyms
Netrin receptor UNC5D ;Protein unc-5 homolog 4;Protein unc-5 homolog D
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG