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SPAG8 Polyclonal Antibody

CAT: 0965-JOT-AP14405-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP14405-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Al
CAS Number
9007-83-4
Synonyms
Sperm-associated antigen 8 ;HSD-1;Sperm membrane protein 1;SMP-1;Sperm membrane protein BS-84
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG

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