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MLL Polyclonal Antibody

CAT: 0965-JOT-AP11380-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP11380-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.
CAS Number
9007-83-4
Synonyms
Histone-lysine N-methyltransferase MLL ;EC 2.1.1.43;ALL-1;CXXC-type zinc finger protein 7;Lysine N-methyltransferase 2A;KMT2A;Trithorax-like protein;Zinc finger protein HRX [Cleaved into:; Histone-lysine N-methyltransferase MLL; EC 2.1.1.43; ALL-1; CXXC-type zinc finger protein 7; Lysine N-methyltransferase 2A; KMT2A; Trithorax-like protein; Zinc finger protein HRX; MLL cleavage product N320; N-terminal cleavage product of 320 kDa; p320; MLL cleavage product C180; C-terminal cleavage product of 180 kDa; p180;
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide from human protein at AA range: 3850-3900
Clonality
Polyclonal
Applications
WB, IHC-p, IF, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG

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