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MIB2 Polyclonal Antibody

CAT: 0965-JOT-AP11327-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP11327-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated. Possibly via autoubiquitination.,Contains 1 ZZ-type zinc finger.,Contains 2 MIB/HERC2 domains.,Contains 2 RING-type zinc fingers.,Contains 9 ANK repeats.,subcellular location:Colocalizes with endosomal compartments.,subunit:Interacts with actin monomer.,tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.,
CAS Number
9007-83-4
Synonyms
E3 ubiquitin-protein ligase MIB2 ;EC 6.3.2.-;Mind bomb homolog 2;Novel zinc finger protein;Novelzin;Putative NF-kappa-B-activating protein 002N;Skeletrophin;Zinc finger ZZ type with ankyri
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG

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