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HLA-DM beta Polyclonal Antibody

CAT: 0965-JOT-AP10063-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP10063-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
CAS Number
9007-83-4
Synonyms
HLA class II histocompatibility antigen, DM beta chain ;MHC class II antigen DMB;Really interesting new gene 7 protein; HLA class II histocompatibility antigen, DM beta chain; MHC class II antigen DMB; Really interesting new gene 7 protein
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide from human protein at AA range: 40-100
Clonality
Polyclonal
Applications
IHC-p, IF, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG

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