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HLA-DP Alpha1 Polyclonal Antibody

CAT: 0965-JOT-AP04130-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP04130-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: b lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
CAS Number
9007-83-4
Synonyms
HLA-DPA1; HLA-DP1A; HLASB; HLA class II histocompatibility antigen; DP alpha 1 chain; DP(W3); DP(W4); HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II DPA1
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of human HLA-DPα1.
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
29381
Antibody Type
Primary antibody
Isotype
IgG

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