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GCH1 Polyclonal Antibody

CAT: 0965-JOT-AP15708-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP15708-01Size:20 µL
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Background
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
CAS Number
9007-83-4
Synonyms
GTP cyclohydrolase 1 ;EC 3.5.4.16;GTP cyclohydrolase I;GTP-CH-I
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG