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DHI2 Polyclonal Antibody

CAT: 0965-JOT-AP08481-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP08481-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mine
CAS Number
9007-83-4
Synonyms
Corticosteroid 11-beta-dehydrogenase isozyme 2 ;EC 1.1.1.-;11-beta-hydroxysteroid dehydrogenase type 2;11-DH2;11-beta-HSD2;11-beta-hydroxysteroid dehydrogenase type II;-HSD11 type II;NAD-d
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG

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