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Acetyl Kine Polyclonal Antibody

CAT: 0965-JOT-AP14070-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP14070-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acetylation of lysine| like phosphorylation of serine| threonine or tyrosine| is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A| H2B| H3| and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) .Signaling resulting in acetylation/deacetylation of histones| transcription factors| and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity| cell growth| differentiation| and apoptosis.Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism| longevity| actin polymerization| and nuclear transport.The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases| and HDACs have become promising targets for anti-cancer drugs currently in development.
CAS Number
9007-83-4
Synonyms
0
Host
Rabbit
Reactivity
Species independent
Immunogen
Recombinant Protein of Acetyl Kine
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Antibody Type
Primary antibody
Isotype
IgG

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