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GLIS2 Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP10186-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP10186-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP)| an autosomal recessive kidney disease characterized by tubular basement membrane disruption| interstitial lymphohistiocytic cell infiltration| and development of cysts at the corticomedullary border of the kidneys.
CAS Number
9007-83-4
Synonyms
GLIS2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human GLIS2
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
57640
Antibody Type
Primary antibody
Isotype
IgG