Products for Research Use Only

CE104 Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP01359-01Size: 20 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0965-JOT-AP01359-01Size:20 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes a centrosomal protein required for ciliogenesis and for ciliary tip structural integrity. The mammalian protein contains three amino-terminal hydrophobic domains| two glycosylation sites| four cysteine-rich motifs| and two regions with homology to the glutamate receptor ionotropic| NMDA 1 protein. During ciliogenesis| the encoded protein translocates from the distal tips of the centrioles to the tip of the elongating cilium. Knockdown of the protein in human retinal pigment cells results in severe defects in ciliogenesis with structural deformities at the ciliary tips. Allelic variants of this gene are associated with the autosomal-recessive disorder Joubert syndrome| which is characterized by a distinctive mid-hindbrain and cerebellar malformation| oculomotor apraxia| irregular breathing| developmental delay| and ataxia.
CAS Number
9007-83-4
Synonyms
CE104
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human CE104
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
101750
Antibody Type
Primary antibody
Isotype
IgG