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1A68 Rabbit Polyclonal Antibody

CAT: 0965-JOT-AP00178-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP00178-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide| exons 2 and 3 encode the alpha1 and alpha2 domains| which both bind the peptide| exon 4 encodes the alpha3 domain| exon 5 encodes the transmembrane region| and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney trans
CAS Number
9007-83-4
Synonyms
1A68
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from human 1A68
Clonality
Polyclonal
Applications
WB
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
40150
Antibody Type
Primary antibody
Isotype
IgG

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