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TGFBeta2 Polyclonal Antibody

CAT: 0965-JOT-AP08979-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP08979-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TGFB2 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing.
CAS Number
9007-83-4
Synonyms
TGFB2; Transforming growth factor beta-2; TGF-beta-2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; Polyergin
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human TGF beta2. AA range:361-410
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
47748
Antibody Type
Primary antibody
Isotype
IgG

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