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Perforin 1 Polyclonal Antibody

CAT: 0749-ABP57517-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP57517-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by PRF1 (perforin 1) has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Description
Rabbit Anti-Perforin 1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Perforin-1; P1; Cytolysin; Lymphocyte pore-forming protein; PFP
Gene ID
5551
Accession Number
P14222
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from Perforin 1 at AA range: 451-500
Clonality
Polyclonal
Tag
Perforin 1
Applications
WB, IHC, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
61kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Perforin 1 Polyclonal Antibody detects endogenous levels of Perforin 1.
Observed Molecular Weight
61
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-200; ELISA 1:10000-20000
Other Product Names
Perforin-1; P1; Cytolysin; Lymphocyte pore-forming protein; PFP
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P14222
Isotype
Rabbit IgG

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