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PEPC Polyclonal Antibody

CAT: 0965-JOT-AP07055-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP07055-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PGC (progastricsin) encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in PGC are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of PGC is found on chromosome 1
CAS Number
9007-83-4
Synonyms
PGC; Gastricsin; Pepsinogen C
Host
Rabbit
Reactivity
Plants
Immunogen
Synthetic Peptide of PEPC
Clonality
Polyclonal
Applications
WB
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
42426
Antibody Type
Primary antibody
Isotype
IgG