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NFKappaB-p100 Polyclonal Antibody

CAT: 0965-JOT-AP05974-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP05974-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NFKB2 encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. Nuclear factor kappa B subunit 2 encoded by NFKB2 can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for NFKB2 on chromosome 18. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Synonyms
NFKB2; LYT10; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human NF-kappaB p100/p52. AA range:833-882
Clonality
Polyclonal
Applications
WB, IHC-p, IP, IF, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
96749
Antibody Type
Primary antibody
Isotype
IgG