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MUM1 Polyclonal Antibody

CAT: 0965-JOT-AP05664-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP05664-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA double-strand breaks (DSBs) are potentially hazardous lesions that can be induced by ionizing radiation (IR), radiomimetic chemicals, or DNA replication inhibitors. Melanoma associated antigen (mutated) 1 (MUM1, EXPAND1) is a PWWP-domain containing chromatin binding protein involved in maintaining chromatin architecture of interphase chromosomes. In response to DNA damage, EXPAND1/MUM1 accumulates at sites of DNA double strand breaks through direct interaction with DNA repair factor 53BP1. Accumulation of EXPAND1/MUM1 at damaged DNA sites is thought to modify the structure of the chromatin and allow access to other DNA repair factors. 53BP1 activates the checkpoint kinase ATM and promotes DNA double strand break repair via nonhomologous end joining (NHEJ) repair pathway.
CAS Number
9007-83-4
Synonyms
melanoma associated antigen (mutated) 1
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human MUM1. AA range:661-710
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
78636
Antibody Type
Primary antibody
Isotype
IgG

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