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IL-4R Alpha Polyclonal Antibody

CAT: 0965-JOT-AP04505-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP04505-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IL4R encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. Interleukin-4 receptor subunit alpha also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
CAS Number
9007-83-4
Synonyms
IL4R; IL4RA; 582J2.1; Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IL4R. AA range:131-180
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
89658
Antibody Type
Primary antibody
Isotype
IgG

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