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IGF-IIR Polyclonal Antibody

CAT: 0965-JOT-AP04395-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP04395-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IGF2R encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID: 8267611).
CAS Number
9007-83-4
Synonyms
IGF2R; MPRI; Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300;Insulin-like growth factor 2 receptor; Insulin-like growt
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human IGF2R. AA range:2251-2300
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
274276
Antibody Type
Primary antibody
Isotype
IgG

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