Products for Research Use Only
RegisterLogin

FMO3 Polyclonal Antibody

CAT: 0965-JOT-AP03290-01Size: 20 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0965-JOT-AP03290-01Size:20 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.
CAS Number
9007-83-4
Synonyms
FMO3; Dimethylaniline monooxygenase [N-oxide-forming] 3; Dimethylaniline oxidase 3; FMO II; FMO form 2; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human FMO3. AA range:101-150
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
58520
Antibody Type
Primary antibody
Isotype
IgG

Related Products

CatalogName
JOT-EK5185Hu-01Human Dimethylaniline monooxygenase [N-oxide-forming] 3,FMO3 ELISA KIT
JOT-EK1789Ra-01Rat Dimethylaniline Monooxygenase [N-oxide-forming] 3,FMO3 ELISA KIT
JOT-AP10060-01FMO6 Rabbit Polyclonal Antibody
JOT-AP15592-01YTHD2 Polyclonal Antibody
JOT-AP15626-01ZEB1 Polyclonal Antibody
JOT-AP15515-01VWA3A Polyclonal Antibody
JOT-AP15563-01WWTR1 Polyclonal Antibody
JOT-AP15568-01XDH Polyclonal Antibody
JOT-AP15664-01ZN713 Polyclonal Antibody
JOT-AP15660-01ZN574 Polyclonal Antibody

Alternative Products

CatalogName
MBS2534563-01FMO3 Polyclonal Antibody
GTR17870098Fmo3 Rabbit Polyclonal Antibody
NBP1-82415Rabbit Polyclonal FMO3 Antibody
H00002328-B01PMouse Polyclonal FMO3 Antibody

Popular Products