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FGFR-3 Polyclonal Antibody

CAT: 0965-JOT-AP03225-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP03225-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FGFR3 encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
CAS Number
9007-83-4
Synonyms
FGFR3; JTK4; Fibroblast growth factor receptor 3; FGFR-3; CD antigen CD333
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human FGFR3. AA range:131-180
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
87710
Antibody Type
Primary antibody
Isotype
IgG

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