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EID-1 Polyclonal Antibody

CAT: 0965-JOT-AP02882-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP02882-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
CAS Number
9007-83-4
Synonyms
EID1; C15orf3; CRI1; RBP21; PNAS-22; PTD014; EP300-interacting inhibitor of differentiation 1; 21 kDa pRb-associated protein; CREBBP/EP300 inhibitory protein 1; E1A-like inhibitor of differentiation 1
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human EID1. AA range:71-120
Clonality
Polyclonal
Applications
WB, IHC-p, IF, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
20876
Antibody Type
Primary antibody
Isotype
IgG