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DR3 Polyclonal Antibody

CAT: 0965-JOT-AP02724-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP02724-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tumor necrosis factor receptor superfamily member 25 encoded by TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
CAS Number
9007-83-4
Synonyms
TNFRSF25; APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; Tumor necrosis factor receptor superfamily member 25; Apo-3; Apoptosis-inducing receptor AIR;Apoptosis-mediating receptor DR3; Apoptosis-mediating recep
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from DR3 . at AA range: 230-310
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
45385
Antibody Type
Primary antibody
Isotype
IgG

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