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Doublecortin Polyclonal Antibody

CAT: 0965-JOT-AP02708-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP02708-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DCX encodes a member of the doublecortin family. Neuronal migration protein doublecortin encoded by DCX is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Synonyms
DCX; DBCN; LISX; Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Doublecortin. AA range:346-395
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
44925
Antibody Type
Primary antibody
Isotype
IgG

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