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Polyclonal Antibody to Doublecortin

CAT: 0793-35-1798-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-35-1798-50Size:50 μL
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Description
Seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of an overlapping, but distinct, signaling pathways that promote neuronal migration.
Product Name Alternative
DCX|| DC|| DBCN
Gene Name
DCX
Gene ID
1641
UniProt
O43602
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around aa.413~417 (P-T-S-P-G) derived from Human Doublecortin.
Target Antigen
Doublecortin
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 40-45kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG

UniProtKB · O43602

Neuronal migration protein doublecortin

DCX_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43602
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DCX
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NFY6, A9Z1V8, D3DUY8, D3DUY9, D3DUZ0, O43911, Q5JYZ5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

Cell projectionCytoplasmMicrotubule

Molecular function

Developmental protein

Biological process

DifferentiationNeurogenesis

Disease

Disease variantEpilepsyLissencephaly

PTM

PhosphoproteinUbl conjugation

Domain

Repeat

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JOT-AP02708-01Doublecortin Polyclonal Antibody
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