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COL4A1 Polyclonal Antibody

CAT: 0965-JOT-AP02082-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP02082-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
COL4A1 encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in COL4A1 cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Synonyms
COL4A1; Collagen alpha-1(IV) chain
Host
Rabbit
Reactivity
Human;Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Collagen IV. AA range:11-60
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
160615
Antibody Type
Primary antibody
Isotype
IgG

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