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AZ1 Polyclonal Antibody

CAT: 0965-JOT-AP00784-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP00784-01Size:20 µL
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Background
The protein encoded by OAZ1 belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. OAZ1 encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.
CAS Number
9007-83-4
Synonyms
OAZ1; OAZ; Ornithine decarboxylase antizyme 1; ODC-Az
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63
Clonality
Polyclonal
Applications
IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
25406
Antibody Type
Primary antibody
Isotype
IgG

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