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AKAP 13 Polyclonal Antibody

CAT: 0965-JOT-AP00320-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP00320-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.
CAS Number
9007-83-4
Synonyms
AKAP13; BRX; HT31; LBC; A-kinase anchor protein 13; AKAP-13; AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human AKAP13. AA range:721-770
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
307550
Antibody Type
Primary antibody
Isotype
IgG

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