Products for Research Use Only
RegisterLogin

GSK4418959

CAT: 0804-HY-169422-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-169422-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC) [1].
CAS Number
3064599-36-3
Product Name Alternative
IDE275
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wrn-inhibitor-16.html
Concentration
10mM
Purity
99.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C(F)(F)F)C=C1F)[C@@H]2CCC[C@H](C3=CC=C(N(C)S(=O)(C4=CC(N=C(C)N5C)=C5C=C4)=O)C=C3)[C@H]2C(O)=O
Molecular Formula
C31H30F4N4O5S
Molecular Weight
646.65
References & Citations
[1]Yanhua Rao, et al. Abstract 6393: Patient selection, target engagement and pharmacodynamic markers of WRN inhibitor GSK4418959 (IDE275) . Cancer Res (2025) 85 (8_Supplement_1) : 6393.|[2]Joshua P. Taygerly, et al. Abstract 5750: Discovery of GSK4418959 (IDE275) : A novel, non-covalent, reversible Werner Helicase inhibitor and a new potential therapeutic for the treatment of MSI-H cancers. Cancer Res (2025) 85 (8_Supplement_1) : 5750.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
T204089-01GSK4418959
TYD-04405-01GSK4418959 (enantiomer)

Popular Products