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GSK4418959

CAT: 0931-T204089-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T204089-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3064599-36-3
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Purity
0.99141
Bioactivity
GSK4418959 (IDE275) is a non-covalent, reversible, selective, and orally active inhibitor of the Werner syndrome helicase (WRN helicase) . GSK4418959 inhibits both ATPase and DNA unwinding activities of WRN helicase in an ATP-competitive manner. GSK4418959 is a valuable chemical tool for the study of microsatellite instability-high (MSI-H) cancers, where WRN helicase plays an essential role in maintaining genomic stability.
Smiles
C(O)(=O)[C@@H]1[C@H](CCC[C@H]1C(NC2=C(F)C=C(C(F)(F)F)C=C2)=O)C3=CC=C(N(S(=O)(=O)C=4C=C5C(=CC4)N(C)C(C)=N5)C)C=C3
Molecular Formula
C31H30F4N4O5S
Molecular Weight
646.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-169422-01GSK4418959
HY-169422A-01GSK4418959 (enantiomer)

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