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LW1564

CAT: 0804-HY-170027Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170027Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LW1564 is an inhibitor for HIF-1α with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model[1].
CAS Number
2668337-39-9
UNSPSC
12352005
Target
AMPK; HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(COC1=CC=C(C23CC4CC(C3)CC(C4)(C2)C(N5CC6=CC(OC)=C(C=C6CC5)OC)=O)C=C1)N7CCN(CC7)CC8=CC=C(C(F)(F)F)C=C8
Molecular Formula
C42H48F3N3O5
Molecular Weight
731.84
References & Citations
[1]Kim I, et al., The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF) -1α accumulation. Exp Mol Med. 2020 Nov;52 (11) :1845-1856.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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