CD80 Recombinant Protein

CAT: 0384-NCP0229-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0384-NCP0229-01Size:500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation. CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions. Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity.
CAS Number
9000-83-3
Swiss Prot
P33681
Modification Site
NdeI-XhoI
Expression System
Pet-22b (+)
Tag
His-tag
Purity
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE) .
Solubility
PBS, 4M Urea, PH7.4
Molecular Weight
~23kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Host or Source
E.coli
AA Sequence
GTTATCCATGTTACCAAAGAAGTGAAAGAAGTTGCCACCCTGAGTTGCGGTCATAATGTGAGTGTTGAAGAACTGGCACAGACCCGTATCTATTGGCAGAAAGAAAAAAAAATGGTGCTGACCATGATGAGCGGCGATATGAATATCTGGCCGGAATATAAAAATCGTACCATCTTCGATATCACCAATAATCTGAGTATTGTTATCCTGGCACTGCGTCCGAGTGATGAAGGTACCTATGAATGTGTTGTGCTGAAATATGAAAAGGATGCCTTCAAACGTGAACATCTGGCAGAAGTTACCCTGAGTGTGAAAGCAGACTTCCCGACCCCGAGCATTAGCGACTTCGAAATTCCGACCAGTAATATTCGTCGTATTATCTGTAGCACCAGTGGTGGCTTCCCGGAACCGCATCTGAGCTGGCTGGAAAATGGTGAAGAACTGAATGCCATTAATACCACCGTGAGCCAGGATCCGGAAACCGAACTGTATGCAGTGAGTAGTAAACTGGACTTCAATATGACCACCAATCATAGCTTCATGTGTCTGATTAAATACGGTCATCTGCGCGTGAATCAGACCTTCAATTGGAATACCACCAAACAGGAACACTTCCCGGATAAT

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