Products for Research Use Only
RegisterLogin

RecombinantMCP-2/CCL8, Human

CAT: 0384-BK0126-01Size: 5 μgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-BK0126-01Size:5 μg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MCP-2 is a member of the chemokines, a group of 70-80 residue proteins sharing substantial sequence similarity. Within the chemokines, MCP-2 belongs to the CC subfamily, and is a member of the Monocyte Chemoattractant Proteins (MCPs), which includes MCP-1, MCP-2, MCP-3, MCP-4, and MCP-5. MCP-2 shares 60% homology with MCP-1, and both proteins can undergo reversible dimerization. The main receptors of MCP-2 are G-protein coupled receptors CCR1 and CCR5. MCP-2 is a potential target in HIV-1 infected human glial cells as it may play a role in the modulation of viral spread in the brain. Recently, researchers found that mouse MCP-2 is expressed in the skin as a novel agonist of CCR8 and plays a role in eosinophilic inflammation.Recombinant human MCP-2/CCL8 (rhMCP-2) produced in E.coli is a single non-glycosylated polypeptide chain containing 76 amino acids. A fully biologically active molecule, rhMCP-2 has a molecular mass of 8.9kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% by SDS-PAGE analysis.
Bioactivity
ED50< 0.5 µg/mL, measured by the FLIPR assay using CHO cells transfected with human CCR5, the receptor of human CCL8, corresponding to a specific activity of > 2 x 10ˆ3 units/mg.
Reconstitution
Reconstituted in ddH2O at 100 μg/mL.
Molecular Weight
8.9 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human MCP-2/CCL8 (rhMCP-2) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhMCP-2 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
QPD SVSIPITCCF NVINRKIPIQ RLESYTRITN IQCPKEAVIF KTKRGKEVCA DPKERWVRDS MKHLDQIFQN LKP

Related Products

CatalogName
BK0125-01RecombinantMCP-1/CCL2, Human
BK0321-01RecombinantMCP-1/CCL2, Rat
BK0320-01RecombinantMCP-1/CCL2, Mouse
BK0264-01RecombinantMCP‑3/CCL7, Human (CHO-expressed)
BK0265-01RecombinantMCP‑3/MARC/CCL7, Mouse
BK0266-01RecombinantMCP-5/CCL12, Mouse
PR2030-01Recombinant Murine MCP-2/CCL8 (rMuMCP-2/CCL8)
PR1087-01Recombinant Human MCP-2 (rHu MCP-2/CCL8)
BS70757-01CCL8 polyclonal antibody
BK0010-01RecombinantBMP-2, Human

Alternative Products

CatalogName
BK0126RecombinantMCP-2/CCL8,Human
BK0125RecombinantMCP-1/CCL2,Human
GTR18990488-01RecombinantMCP-1/CCL2, Human
RC315-19MCP-2, CCL8, human
HY-P7238-01MCP-2/CCL8, Human
MBS691949-01Human MCP-2 (CCL8)
E55A12434Human CCL8/MCP-2
BK0264RecombinantMCP‑3/CCL7,Human(CHO-expressed)
GTR18990277-01RecombinantMCP‐3/CCL7, Human (CHO-expressed)
YP-W200184-01Human ccl8 (ccl8) ELISA Kit

Popular Products