MAP3K8/COT Recombinant Rabbit mAb

• Background:

  This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT

• Swiss Prot:

  P41279

• Reactivity:

  Human

• Immunogen:

  A synthetic peptide of human MAP3K8/COT

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:1000

• Purity:

  Affinity Purification

• Modification:

  Unmodification

• Molecular Weight:

  53 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3