CD4 Recombinant Rabbit mAb

• Background :

  Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs) . In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells.

• Structure Composition :

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative :

  L3T4; Ly-4

• Swiss Prot :

  P06332

• Reactivity :

  Mouse

• Immunogen :

  Recombinant protein of mouse CD4

• Conjugation :

  Unconjugated

• Applications :

  WB, IHC, IP

• Purity :

  Affinity Purification

• Modification :

  Unmodification

• Molecular Weight :

  51 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  IgG

• Applications Notes :

  Western blot analysis of extracts from Mouse thymus tissue at 1:1000.

• Host or Source :

  Rabbit

• CAS Number :

  9000-83-3