S100B Recombinant Rabbit mAb

• Background:

  The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]

• Structure Composition:

  Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

• Product Name Alternative:

  NEF; S100; S100-B; S100beta

• Swiss Prot:

  P04271

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human S100B

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, ICC/IF, IP

• Purity:

  Affinity Purification

• Modification:

  Unmodification

• Molecular Weight:

  11 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot detection of S100 beta in Rat Brain lysates using S100 beta antibody (1:500 diluted) .

• Host or Source:

  Rabbit

• CAS Number:

  9000-83-3