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USP13 Recombinant Rabbit mAb

CAT: 0384-BS45151-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS45151-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD) . Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13.
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
ISOT3; IsoT-3
Swiss Prot
Q92995
Reactivity
Human, Mouse
Immunogen
A synthetic peptide of human USP13
Conjugation
Unconjugated
Applications
WB, ICC/IF, FC, IP
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
97 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of USP13 in U2OS cell lysates using USP13 antibody (1:500 diluted) .
Host or Source
Rabbit

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