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YTHDC2 Rabbit monoclonal antibody

CAT: 0384-MB66466-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66466-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
YTH domain-containing protein 1 (YTHDC1) and YTH domain-containing protein 2 (YTHDC2) both belong to a family of proteins that bind to RNA. YTHDC1 and YTHDC2 both recognize and bind to N6-methyladenosine (m6A) -containing RNAs; binding is mediated through the YTH domains . m6A is a modification that is present at internal sites of mRNAs and some non-coding RNAs and plays a role in regulating mRNA splicing, processing, and stability. YTHDC1, also known as splicing factor YT521, regulates alternative splicing by functioning as a key regulator of exon-inclusion or exon-skipping. YTHDC1 promotes exon-inclusion by recruiting pre-mRNA splicing factor SRSF3 to regions containing m6A, while repressing exon-skipping by blocking SRSF10 binding to these same regions. Increased expression of YTHDC1 promotes malignant endometrial carcinoma (EC) through alternative splicing of vascular endothelial growth factor A (VEGF-A), resulting in an increase in VEGF-165 isoform and increased EC cell invasion. YTHDC2 functions to enhance the translation efficiency of target mRNAs and may play a role in spermatogenesis.
CAS Number
9007-83-4
Structure Composition
Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.
Product Name Alternative
Probable ATP-dependent RNA helicase YTHDC2
Swiss Prot
Q9H6S0
Reactivity
Human
Immunogen
Recombinant protein of mouse YTHDC2
Conjugation
Unconjugated
Applications
WB, IP
Dilution
WB (1/500 - 1/1000), IP (1/10 - 1/50)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 160 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of YTHDC2 protein.
Applications Notes
Western blot analysis of YTHDC2 expression in Hela (A), A549 (B), HL60 (C), U251 (D), U87MG (E) whole cell lysates.
Host or Source
Rabbit

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